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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2l1
Name: Bcl2-like 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l1decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of BCL2L1 proteinPMID:19616567
Bcl2l1increases expressionEXP 6480464CTDsodium arsenite results in increased expression of BCL2L1 proteinPMID:20830294
Bcl2l1multiple interactionsEXP 6480464CTDTaurine inhibits the reaction [sodium arsenite results in decreased expression of BCL2L1 protein]; Taurine inhibits the reaction [sodium arsenite results in increased expression of BCL2L1 protein alternative form]PMID:19616567 PMID:20830294
Bcl2l1affects expressionISOBCL2L1 (Homo sapiens)6480464CTDsodium arsenite affects the expression of BCL2L1 mRNAPMID:29319823
Bcl2l1affects localizationISOBcl2l1 (Mus musculus)6480464CTDsodium arsenite affects the localization of BCL2L1 proteinPMID:16166651
Bcl2l1decreases expressionISOBcl2l1 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of BCL2L1 mRNAPMID:16014739
Bcl2l1decreases expressionISOBCL2L1 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of BCL2L1 mRNA; sodium arsenite results in decreased expression of BCL2L1 proteinPMID:12760830 PMID:26404762 PMID:28586017 PMID:31139082
Bcl2l1increases expressionISOBcl2l1 (Mus musculus)6480464CTDsodium arsenite results in increased expression of BCL2L1 mRNAPMID:17451858
Bcl2l1increases expressionISOBCL2L1 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of BCL2L1 mRNA; sodium arsenite results in increased expression of BCL2L1 proteinPMID:24431212 PMID:24570342
Bcl2l1multiple interactionsISOBCL2L1 (Homo sapiens)6480464CTD[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of BCL2L1 protein; [sodium arsenite results in increased abundance of Arsenic] promotes the reaction [ATF3 protein binds to BCL2L1 promoter]; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2L1 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2L1 protein; ATF3 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2L1 mRNA]; ATF3 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2L1 protein]; LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of BCL2L1 mRNA]; pterostilbene inhibits the reaction [sodium arsenite results in decreased expression of BCL2L1 protein]; sodium arsenite promotes the reaction [BBC3 protein binds to BCL2L1 protein]; tetramethylpyrazine inhibits the reaction [sodium arsenite results in decreased expression of BCL2L1 protein]PMID:24570342 PMID:26404762 PMID:31139082 PMID:32802178 PMID:33921748 PMID:34798143
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