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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303075
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsp90ab1
Name: heat shock protein 90 alpha family class B member 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsp90ab1increases expressionEXP 6480464CTDsodium arsenite results in increased expression of HSP90AB1 proteinPMID:16456883
Hsp90ab1multiple interactionsEXP 6480464CTDBenzo(a)pyrene promotes the reaction [sodium arsenite results in increased expression of HSP90AB1 protein]; sodium arsenite promotes the reaction [Benzo(a)pyrene results in increased expression of HSP90AB1 protein]PMID:16456883
Hsp90ab1decreases expressionISOHSP90AB1 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of HSP90AB1 proteinPMID:21925251
Hsp90ab1decreases expressionISOHsp90ab1 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of HSP90AB1 mRNAPMID:18996350
Hsp90ab1increases expressionISOHSP90AB1 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of HSP90AB1 mRNAPMID:12119132
Hsp90ab1increases expressionISOHsp90ab1 (Mus musculus)6480464CTDsodium arsenite results in increased expression of HSP90AB1 mRNAPMID:16014739 PMID:16322246
Hsp90ab1multiple interactionsISOHsp90ab1 (Mus musculus)6480464CTDATM protein affects the reaction [sodium arsenite results in decreased expression of HSP90AB1 mRNA]; CHEK2 protein affects the reaction [sodium arsenite results in decreased expression of HSP90AB1 mRNA]; sodium arsenite promotes the reaction [TRP53 protein binds to HSP90AB1 promoter]PMID:18996350
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