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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553531 Species: Mus musculus RGD Object: Gene Symbol: Rac1 Name: RAS-related C3 botulinum substrate 1

Acc ID: CHEBI:2948 Term: azathioprine Definition: A thiopurine that has formula C9H7N7O2S. CasRN: 446-86-6 Chemical ID: MESH:D001379

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1605432	6480464	CTD	Azathioprine inhibits the reaction [RAC1 protein binds to STAT3 protein]	PMID:12697733
decreases activity	ISO	RGD:1605432	6480464	CTD	Azathioprine results in decreased activity of RAC1 protein	PMID:12697733
affects binding	ISO	RGD:1605432	6480464	CTD	Azathioprine metabolite binds to RAC1 protein	PMID:12697733
affects response to substance	ISO	RGD:1605432	6480464	CTD	RAC1 gene polymorphism affects the susceptibility to Azathioprine	PMID:21372752