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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2623
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fmr1
Name: fragile X messenger ribonucleoprotein 1
Acc ID: CHEBI:29474
Term: (S)-3,5-dihydroxyphenylglycine
Definition: A glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups.
Chemical ID: MESH:C079215
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fmr1affects localizationEXP 6480464CTD3,5-dihydroxyphenylglycine affects the localization of FMR1 mRNA; 3,5-dihydroxyphenylglycine affects the localization of FMR1 proteinPMID:15028757
Fmr1multiple interactionsEXP 6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 protein]; Ro 32-0432 inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 mRNA]; Ro 32-0432 inhibits the reaction [3,5-dihydroxyphenylglycine affects the localization of FMR1 protein]PMID:15028757
Fmr1multiple interactionsISOFmr1 (Mus musculus)6480464CTD3,5-dihydroxyphenylglycine inhibits the reaction [FMR1 gene mutant form results in increased activity of MGLL]PMID:20393458
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