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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:2922
Term: auranofin
Definition: An S-glycosyl compound consisting of 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranose with the sufur atom coordinated to (triethylphosphoranylidene)gold. It is administered orally for the treatment of active progressive rheumatoid arthritis.
Chemical ID: MESH:D001310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3decreases expressionISOSTAT3 (Homo sapiens)6480464CTDAuranofin results in decreased expression of STAT3 protein modified formPMID:20542334
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTD[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 proteinPMID:20542334
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