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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11219 Species: Mus musculus RGD Object: Gene Symbol: Rb1 Name: retinoblastoma 1

Acc ID: CHEBI:2922 Term: auranofin Definition: An S-glycosyl compound consisting of 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranose with the sufur atom coordinated to (triethylphosphoranylidene)gold. It is administered orally for the treatment of active progressive rheumatoid arthritis. CasRN: 34031-32-8 Chemical ID: MESH:D001310

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases phosphorylation	ISO	RGD:731712	6480464	CTD	Auranofin results in decreased phosphorylation of RB1 protein	PMID:20542334