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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3multiple interactionsEXP 6480464CTD[Vitamin E co-treated with Ascorbic Acid] inhibits the reaction [Dexamethasone results in decreased expression of NOS3 protein]; Ascorbic Acid inhibits the reaction [Formaldehyde results in decreased expression of NOS3 mRNA]; Ascorbic Acid inhibits the reaction [lead acetate results in increased expression of NOS3 protein]PMID:11729227 PMID:20068362 PMID:27020608
Nos3increases activityISONOS3 (Homo sapiens)6480464CTDAscorbic Acid results in increased activity of NOS3 proteinPMID:11243424
Nos3increases phosphorylationISONos3 (Mus musculus)6480464CTDAscorbic Acid results in increased phosphorylation of NOS3 proteinPMID:21570463
Nos3multiple interactionsISONOS3 (Homo sapiens)6480464CTD[Isosorbide Dinitrate co-treated with Ascorbic Acid] affects the expression of NOS3 mRNAPMID:15719745
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