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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:29069
Term: phthalic acid
Definition: A benzenedicarboxylic acid cosisting of two carboxy groups at ortho positions.
Chemical ID: MESH:C032279
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDphthalic acid analog binds to ESR1 proteinPMID:14579009
Esr1increases degradationISOESR1 (Homo sapiens)6480464CTDphthalic acid results in increased degradation of ESR1 proteinPMID:14702340
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDphthalic acid analog inhibits the reaction [Estradiol binds to ESR1 protein]; phthalic acid binds to and results in increased activity of ESR1 protein; Tamoxifen inhibits the reaction [phthalic acid metabolite binds to and results in increased activity of ESR1 protein]PMID:14579009 PMID:15840436
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