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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962 Species: Homo sapiens RGD Object: Gene Symbol: CYP3A4 Name: cytochrome P450, family 3, subfamily A, polypeptide 4

Acc ID: CHEBI:29027 Term: trans-1,2-dichloroethene Definition: A 1,2-dichloroethene that has formula C2H2Cl2. CasRN: 540-59-0 Chemical ID: MESH:C035384

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:708379	6480464	CTD	1,2-dichloroethylene results in decreased activity of CYP3A2 protein	PMID:9493318
decreases expression	ISO	RGD:708379	6480464	CTD	1,2-dichloroethylene results in decreased expression of CYP3A2 protein	PMID:9493318