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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:28955
Term: 2-methoxy-17beta-estradiol
Definition: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.
Chemical ID: MESH:C022830
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2affects response to substanceISOSOD2 (Homo sapiens)6480464CTDSOD2 protein affects the susceptibility to 2-MethoxyestradiolPMID:17895890
Sod2increases response to substanceISOSOD2 (Homo sapiens)6480464CTDSOD2 protein results in increased susceptibility to 2-MethoxyestradiolPMID:22547077
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTD2-Methoxyestradiol inhibits the reaction [Curcumin results in increased expression of SOD2 mRNA]PMID:25822711
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