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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620752
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1d1
Name: aldo-keto reductase family 1, member D1
Acc ID: CHEBI:28952
Term: 5alpha-pregnane-3,20-dione
Definition: A C21-steroid hormone that is 5alpha-pregnane substituted by oxo groups at positions 3 and 20. It is a metabolite of progestrone.
Chemical ID: MESH:D043582
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1d1increases chemical synthesisISOAkr1d1 (Mus musculus)6480464CTDAKR1D1 protein alternative form results in increased chemical synthesis of 5-alpha-DihydroprogesteronePMID:30928400
Akr1d1increases chemical synthesisISOAKR1D1 (Homo sapiens)6480464CTDAKR1D1 protein results in increased chemical synthesis of 5-alpha-DihydroprogesteronePMID:18624455
Akr1d1multiple interactionsISOAkr1d1 (Mus musculus)6480464CTD[AKR1D1 protein alternative form results in increased reduction of Progesterone] which results in increased chemical synthesis of 5-alpha-DihydroprogesteronePMID:30928400
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