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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3610
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rxra
Name: retinoid X receptor alpha
Acc ID: CHEBI:28940
Term: calciol
Definition: A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.
Chemical ID: MESH:D002762
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rxraaffects localizationISORXRA (Homo sapiens)6480464CTDCholecalciferol affects the localization of RXRA proteinPMID:36066700
Rxramultiple interactionsISORXRA (Homo sapiens)6480464CTD[Cholecalciferol co-treated with Tretinoin] promotes the reaction [[VDR protein binds to RXRA protein] which binds to SLCO1A2 promoter]; Aflatoxin B1 inhibits the reaction [Cholecalciferol affects the localization of RXRA protein]; Cholecalciferol inhibits the reaction [RXRA protein binds to VDR promoter]; Cholecalciferol promotes the reaction [RXRA protein binds to VDR enhancer]PMID:22474172 PMID:36066700
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