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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3increases expressionEXP 6480464CTDAcetylcysteine results in increased expression of NOS3 proteinPMID:17321519
Nos3multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of NOS3 protein]; Acetylcysteine inhibits the reaction [Triglycerides results in decreased expression of NOS3 mRNA]; Acetylcysteine inhibits the reaction [Triglycerides results in decreased expression of NOS3 protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of NOS3 protein]]PMID:16140881 PMID:21912612
Nos3multiple interactionsISONOS3 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Aldrin results in increased expression of NOS3 mRNA]; Acetylcysteine inhibits the reaction [alpha-hexachlorocyclohexane results in increased expression of NOS3 mRNA]; Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of NOS3 mRNA]; Acetylcysteine inhibits the reaction [Endosulfan results in increased expression of NOS3 mRNA]; Acetylcysteine inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 mRNA]; Acetylcysteine inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 protein]; Acetylcysteine inhibits the reaction [Oxygen deficiency results in decreased expression of NOS3 protein]; Acetylcysteine inhibits the reaction [TNF results in decreased expression of NOS3 protein]PMID:17026986 PMID:19837105 PMID:26906511 PMID:28273962
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