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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305769
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pink1
Name: PTEN induced kinase 1
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pink1multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Cadmium results in increased expression of PINK1 mRNA]; Acetylcysteine inhibits the reaction [Lead results in increased expression of PINK1 mRNA]PMID:34816377
Pink1multiple interactionsISOPINK1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [quinone results in increased expression of PINK1 protein]PMID:29567065
Pink1multiple interactionsISOPink1 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of PINK1]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PINK1 protein]; Acetylcysteine inhibits the reaction [tricalcium phosphate results in increased expression of PINK1 protein]PMID:25464205 PMID:34547296 PMID:37678662 PMID:37692514
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