GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | affects binding | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Mechlorethamine binds to TP53 protein | PMID:35312310 | Tp53 | affects response to substance | ISO | Trp53 (Mus musculus) | 6480464 | CTD | TRP53 affects the susceptibility to Mechlorethamine; TRP53 protein affects the susceptibility to Mechlorethamine | PMID:12185594 PMID:23845566 | Tp53 | decreases activity | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Mechlorethamine results in decreased activity of TP53 protein | PMID:35312310 | Tp53 | increases alkylation | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Mechlorethamine results in increased alkylation of TP53 protein | PMID:35312310 | Tp53 | increases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Mechlorethamine results in increased expression of TP53 protein | PMID:16738803 | Tp53 | increases stability | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Mechlorethamine results in increased stability of TP53 protein | PMID:35312310 | Tp53 | multiple interactions | ISO | Trp53 (Mus musculus) | 6480464 | CTD | Mechlorethamine results in increased phosphorylation of and results in increased expression of TRP53 protein | PMID:25891025 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Mechlorethamine results in increased expression of and affects the localization of TP53 protein; Mechlorethamine results in increased phosphorylation of and results in increased acetylation of TP53 protein | PMID:35312310 | |
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