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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:28925
Term: mechlorethamine
Definition: A nitrogen mustard that has formula C5H11Cl2N.
Chemical ID: MESH:D008466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53affects bindingISOTP53 (Homo sapiens)6480464CTDMechlorethamine binds to TP53 proteinPMID:35312310
Tp53affects response to substanceISOTrp53 (Mus musculus)6480464CTDTRP53 affects the susceptibility to Mechlorethamine; TRP53 protein affects the susceptibility to MechlorethaminePMID:12185594 PMID:23845566
Tp53decreases activityISOTP53 (Homo sapiens)6480464CTDMechlorethamine results in decreased activity of TP53 proteinPMID:35312310
Tp53increases alkylationISOTP53 (Homo sapiens)6480464CTDMechlorethamine results in increased alkylation of TP53 proteinPMID:35312310
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDMechlorethamine results in increased expression of TP53 proteinPMID:16738803
Tp53increases stabilityISOTP53 (Homo sapiens)6480464CTDMechlorethamine results in increased stability of TP53 proteinPMID:35312310
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTDMechlorethamine results in increased phosphorylation of and results in increased expression of TRP53 proteinPMID:25891025
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTDMechlorethamine results in increased expression of and affects the localization of TP53 protein; Mechlorethamine results in increased phosphorylation of and results in increased acetylation of TP53 proteinPMID:35312310
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