GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Comt | increases methylation | EXP | | 6480464 | CTD | COMT protein results in increased methylation of Epinephrine | PMID:10064789 | Comt | multiple interactions | EXP | | 6480464 | CTD | [COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine] | PMID:10064789 PMID:8821542 | Comt | increases methylation | ISO | COMT (Homo sapiens) | 6480464 | CTD | COMT protein results in increased methylation of Epinephrine | PMID:11160877 | Comt | multiple interactions | ISO | COMT (Homo sapiens) | 6480464 | CTD | [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine | PMID:11248589 | | ||||||||||||||||||||||
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