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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:28869
Term: menadione
Definition: A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.
Chemical ID: MESH:D024483
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases cleavageEXP 6480464CTDVitamin K 3 results in increased cleavage of CASP9 proteinPMID:16310883
Casp9multiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP9 protein]PMID:16310883
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDVitamin K 3 results in increased cleavage of CASP9 proteinPMID:25005833
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTD[sodium arsenite co-treated with Vitamin K 3] results in increased activity of CASP9 protein; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased activity of CASP9 protein]; EUK-134 inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP9 protein]; Vitamin K 3 analog promotes the reaction [Doxorubicin results in increased activity of CASP9 protein]PMID:19082730 PMID:25005833 PMID:29141199
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