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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10439 Species: Mus musculus RGD Object: Gene Symbol: Cyp1b1 Name: cytochrome P450, family 1, subfamily b, polypeptide 1

Acc ID: CHEBI:28851 Term: phenanthrene Definition: A polycyclic aromatic hydrocarbon composed of three fused benzene rings which takes its name from the two terms 'phenyl' and 'anthracene.' CasRN: 85-01-8 Chemical ID: MESH:C031181

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:736765	6480464	CTD	[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1B1 mRNA	PMID:15566942
decreases metabolic processing	ISO	RGD:736765	6480464	CTD	CYP1B1 gene polymorphism results in decreased metabolism of phenanthrene	PMID:17035385
multiple interactions	ISO	RGD:736765	6480464	CTD	CYP1B1 protein results in increased metabolism of and results in increased activity of phenanthrene	PMID:19766613
multiple interactions	ISO	RGD:736765	6480464	CTD	phenanthrene binds to and results in decreased activity of CYP1B1 protein	PMID:19563207