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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:28794
Term: coumarin
Definition: A chromenone having the keto group located at the 2-position.
Chemical ID: MESH:C030123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects expressionEXP 6480464CTDcoumarin affects the expression of CYP1A2 mRNAPMID:16963487
Cyp1a2decreases expressionEXP 6480464CTDcoumarin results in decreased expression of CYP1A2 mRNAPMID:18480146
Cyp1a2increases metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased metabolism of coumarinPMID:34334558
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[CYP1A2 protein results in increased metabolism of coumarin] which results in increased abundance of 2-hydroxyphenylacetic acid; [CYP1A2 protein results in increased metabolism of coumarin] which results in increased abundance of 7-hydroxycoumarinPMID:34334558
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