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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61800
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr2a
Name: 5-hydroxytryptamine receptor 2A
Acc ID: CHEBI:28790
Term: serotonin
Definition: A primary amino compound that is the 5-hydroxy derivative of tryptamine.
Chemical ID: MESH:D012701
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr2aaffects bindingEXP 6480464CTDSerotonin binds to HTR2A proteinPMID:8627522
Htr2aaffects response to substanceEXP 6480464CTDHTR2A protein affects the susceptibility to SerotoninPMID:16528294 PMID:8627522
Htr2amultiple interactionsEXP 6480464CTD[Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in decreased abundance of Serotonin]; [Ketanserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Serotonin; Phenoxybenzamine affects the reaction [Serotonin binds to HTR2A protein]PMID:16528294 PMID:19879056 PMID:8627522
Htr2aaffects response to substanceISOHTR2A (Homo sapiens)6480464CTDHTR2A protein affects the susceptibility to SerotoninPMID:16314884
Htr2adecreases response to substanceISOHTR2A (Homo sapiens)6480464CTDHTR2A gene SNP results in decreased susceptibility to SerotoninPMID:16314884
Htr2aincreases expressionISOHtr2a (Mus musculus)6480464CTDSerotonin results in increased expression of HTR2A mRNAPMID:21083617
Htr2amultiple interactionsISOHtr2a (Mus musculus)6480464CTDHTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]PMID:11880652
Htr2amultiple interactionsISOHTR2A (Homo sapiens)6480464CTD[Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein; Serotonin binds to and results in increased activity of HTR2A proteinPMID:11076827 PMID:16314884
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