GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Htr2a | affects binding | EXP | | 6480464 | CTD | Serotonin binds to HTR2A protein | PMID:8627522 | Htr2a | affects response to substance | EXP | | 6480464 | CTD | HTR2A protein affects the susceptibility to Serotonin | PMID:16528294 PMID:8627522 | Htr2a | multiple interactions | EXP | | 6480464 | CTD | [Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in decreased abundance of Serotonin]; [Ketanserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Serotonin; Phenoxybenzamine affects the reaction [Serotonin binds to HTR2A protein] | PMID:16528294 PMID:19879056 PMID:8627522 | Htr2a | affects response to substance | ISO | HTR2A (Homo sapiens) | 6480464 | CTD | HTR2A protein affects the susceptibility to Serotonin | PMID:16314884 | Htr2a | decreases response to substance | ISO | HTR2A (Homo sapiens) | 6480464 | CTD | HTR2A gene SNP results in decreased susceptibility to Serotonin | PMID:16314884 | Htr2a | increases expression | ISO | Htr2a (Mus musculus) | 6480464 | CTD | Serotonin results in increased expression of HTR2A mRNA | PMID:21083617 | Htr2a | multiple interactions | ISO | Htr2a (Mus musculus) | 6480464 | CTD | HTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein] | PMID:11880652 | Htr2a | multiple interactions | ISO | HTR2A (Homo sapiens) | 6480464 | CTD | [Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein; Serotonin binds to and results in increased activity of HTR2A protein | PMID:11076827 PMID:16314884 | |
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