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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734400 Species: Homo sapiens RGD Object: Gene Symbol: ATP5A1 Name: ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

Acc ID: CHEBI:28787 Term: nitroglycerin Definition: A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain. CasRN: 55-63-0 Chemical ID: MESH:D005996

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:619993	6480464	CTD	Nitroglycerin results in decreased expression of ATP5A1 mRNA	PMID:12102619