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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620574 Species: Rattus norvegicus RGD Object: Gene Symbol: Cybb Name: cytochrome b-245, beta polypeptide

Acc ID: CHEBI:28787 Term: nitroglycerin Definition: A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain. CasRN: 55-63-0 Chemical ID: MESH:D005996

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:733265	6480464	CTD	CYBB gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]	PMID:18522491
decreases response to substance	ISO	RGD:733265	6480464	CTD	CYBB gene mutant form results in decreased susceptibility to Nitroglycerin	PMID:18522491
multiple interactions	ISO	RGD:733265	6480464	CTD	rosuvastatin inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]	PMID:16633368
increases expression	ISO	RGD:733265	6480464	CTD	Nitroglycerin results in increased expression of CYBB mRNA	PMID:16633368
decreases expression	EXP		6480464	CTD	Nitroglycerin results in decreased expression of CYBB mRNA	PMID:17493633