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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619869 Species: Rattus norvegicus RGD Object: Gene Symbol: Cxcl1 Name: chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

Acc ID: CHEBI:28775 Term: hesperidin Definition: A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. CasRN: 520-26-3 Chemical ID: MESH:D006569

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:732415	6480464	CTD	Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]	PMID:17400256