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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731777
Species: Mus musculus
RGD Object: Gene
Symbol: Kcnq1
Name: potassium voltage-gated channel, subfamily Q, member 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnq1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of KCNQ1 proteinPMID:34648132
Kcnq1multiple interactionsEXP 6480464CTDMETTL14 protein promotes the reaction [Doxorubicin results in increased expression of KCNQ1 protein]PMID:34648132
Kcnq1decreases expressionISOKCNQ1 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of KCNQ1 mRNAPMID:26537877 PMID:28940058 PMID:29803840
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