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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708425
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Havcr1
Name: hepatitis A virus cellular receptor 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Havcr1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of HAVCR1 mRNA; Doxorubicin results in increased expression of HAVCR1 proteinPMID:19225054 PMID:31376360 PMID:35987278
Havcr1increases secretionEXP 6480464CTDDoxorubicin results in increased secretion of HAVCR1 proteinPMID:28885000
Havcr1multiple interactionsEXP 6480464CTDAngiotensin II Type 1 Receptor Blockers inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 mRNA]; Angiotensin II Type 1 Receptor Blockers inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 mRNA]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein]; Nicorandil inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein]; Tannic Acid inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 mRNA]PMID:19225054 PMID:31376360 PMID:35987278
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