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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70494
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tert
Name: telomerase reverse transcriptase
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tertdecreases expressionISOTERT (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of TERT mRNA; Doxorubicin results in decreased expression of TERT mRNA alternative formPMID:15003732 PMID:16077987 PMID:36634904
Tertdecreases response to substanceISOTERT (Homo sapiens)6480464CTDTERT mRNA results in decreased susceptibility to DoxorubicinPMID:18396642
Tertincreases expressionISOTERT (Homo sapiens)6480464CTDDoxorubicin results in increased expression of TERT mRNAPMID:18560228
Tertmultiple interactionsISOTERT (Homo sapiens)6480464CTDTP53 protein affects the reaction [Doxorubicin results in decreased expression of TERT mRNA]PMID:36634904
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