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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1b
Name: cyclin-dependent kinase inhibitor 1B
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1baffects expressionISOCDKN1B (Homo sapiens)6480464CTDDoxorubicin affects the expression of CDKN1B mRNA; Doxorubicin affects the expression of CDKN1B proteinPMID:16036217 PMID:16705698 PMID:17893511
Cdkn1bdecreases response to substanceISOCDKN1B (Homo sapiens)6480464CTDCDKN1B results in decreased susceptibility to DoxorubicinPMID:21652059
Cdkn1bincreases expressionISOCDKN1B (Homo sapiens)6480464CTDDoxorubicin results in increased expression of CDKN1B proteinPMID:17935137
Cdkn1bmultiple interactionsISOCDKN1B (Homo sapiens)6480464CTD[Doxorubicin co-treated with Cyclophosphamide] affects the expression of CDKN1B mRNA; wortmannin promotes the reaction [Doxorubicin results in increased expression of CDKN1B protein]PMID:16322899 PMID:17935137
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