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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsraffects expressionEXP 6480464CTDDoxorubicin affects the expression of GSR proteinPMID:15909818
Gsrdecreases activityEXP 6480464CTDDoxorubicin results in decreased activity of GSR proteinPMID:16405037 PMID:20146931
Gsrdecreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of GSR mRNAPMID:17005195 PMID:30928397
Gsrmultiple interactionsEXP 6480464CTDChitosan analog inhibits the reaction [Doxorubicin results in decreased expression of GSR mRNA]; NRG1 protein alternative form inhibits the reaction [Doxorubicin results in decreased expression of GSR mRNA]; Plant Extracts inhibits the reaction [Doxorubicin results in decreased activity of GSR protein]PMID:17005195 PMID:20146931 PMID:30928397
Gsraffects activityISOGSR (Homo sapiens)6480464CTDDoxorubicin affects the activity of GSR proteinPMID:16160061
Gsraffects expressionISOGSR (Homo sapiens)6480464CTDDoxorubicin affects the expression of GSR proteinPMID:16160061
Gsrdecreases activityISOGsr (Mus musculus)6480464CTDDoxorubicin results in decreased activity of GSR proteinPMID:24491677
Gsrdecreases response to substanceISOGSR (Homo sapiens)6480464CTDGSR protein results in decreased susceptibility to DoxorubicinPMID:16160061
Gsrmultiple interactionsISOGSR (Homo sapiens)6480464CTD[Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to Doxorubicin; [Doxorubicin co-treated with GSR protein] affects the metabolism of GlucosePMID:16160061 PMID:1901343
Gsrmultiple interactionsISOGsr (Mus musculus)6480464CTDNAD inhibits the reaction [Doxorubicin results in decreased activity of GSR protein]PMID:24491677
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