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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of TP53 mRNAPMID:27255381
Tp53increases acetylationEXP 6480464CTDDoxorubicin results in increased acetylation of TP53 proteinPMID:34713381
Tp53increases expressionEXP 6480464CTDDoxorubicin results in increased expression of TP53 mRNA; Doxorubicin results in increased expression of TP53 protein; Doxorubicin results in increased expression of TP53 protein modified formPMID:15667795 PMID:15983034 PMID:17285121 PMID:18632596 PMID:18775851 PMID:20470772 PMID:21194538 PMID:22015447 PMID:22155320 PMID:24902966 PMID:25997894 PMID:26318906 PMID:30009776 PMID:30836069 PMID:30885636 PMID:34047412 PMID:34273911 PMID:34713381
Tp53increases phosphorylationEXP 6480464CTDDoxorubicin results in increased phosphorylation of TP53 proteinPMID:32652078
Tp53multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased phosphorylation of TP53 protein]; 4-(((4-carboxybutyl) (2- (5-fluoro-2-((4'-(trifluoromethyl) biphenyl-4-yl)methoxy)phenyl)ethyl) amino)methyl)benzoic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of TP53 protein]; 7-monohydroxyethylrutoside inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; [Doxorubicin affects the reaction [TP53 protein binds to HSPB1 protein]] which results in increased expression of CDKN1A protein; [Glucose deficiency co-treated with Galactose co-treated with Pyruvic Acid] inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; caryophyllene inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Doxorubicin affects the reaction [TP53 protein binds to HSPB1 protein]; Doxorubicin promotes the reaction [SIRT6 protein binds to TP53 protein]; Doxorubicin promotes the reaction [TP53 protein binds to BAX promoter]; Doxorubicin promotes the reaction [TP53 protein binds to BCL2 promoter]; Doxorubicin promotes the reaction [TP53 protein binds to FAS promoter]; Doxorubicin promotes the reaction [TP53 protein binds to FASLG promoter]; Doxorubicin results in increased expression of and results in increased localization of TP53 protein modified form; Doxorubicin results in increased expression of and results in increased phosphorylation of and results in increased stability of and results in increased activity of TP53 protein; Doxorubicin results in increased phosphorylation of and results in increased localization of TP53 protein; Exenatide inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Ginkgo biloba extract inhibits the reaction [Doxorubicin results in increased expression of TP53 mRNA]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]]; kaempferol inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to BAX promoter]]; kaempferol inhibits the reaction [Doxorubicin results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased localization of TP53 protein modified form]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased localization of TP53 protein]; Propofol inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Quercetin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; SHC1 protein promotes the reaction [Doxorubicin results in increased expression of TP53 protein]; SIRT6 protein inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to FAS promoter]]; SIRT6 protein inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to FASLG promoter]]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased acetylation of TP53 protein]; U 0126 inhibits the reaction [Doxorubicin results in increased expression of and results in increased localization of TP53 protein modified form]; U 0126 inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased localization of TP53 protein]; Valsartan inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]PMID:16687611 PMID:17285121 PMID:18263706 PMID:18632596 PMID:18775851 PMID:22015447 PMID:22155320 PMID:24902966 PMID:25997894 PMID:26318906 PMID:30836069 PMID:30885636 PMID:32652078 PMID:34047412 PMID:34273911 PMID:34713381
Tp53affects activityISOTP53 (Homo sapiens)6480464CTDDoxorubicin affects the activity of TP53 proteinPMID:35435491
Tp53affects expressionISOTP53 (Homo sapiens)6480464CTDDoxorubicin affects the expression of TP53 mRNA; Doxorubicin affects the expression of TP53 proteinPMID:12006519 PMID:17893511 PMID:27825931 PMID:35218280
Tp53affects localizationISOTrp53 (Mus musculus)6480464CTDDoxorubicin affects the localization of TRP53 proteinPMID:20955365
Tp53affects localizationISOTP53 (Homo sapiens)6480464CTDDoxorubicin affects the localization of TP53 proteinPMID:19363521 PMID:26025680
Tp53affects response to substanceISOTrp53 (Mus musculus)6480464CTDTRP53 protein mutant form affects the susceptibility to DoxorubicinPMID:24812279
Tp53affects response to substanceISOTP53 (Homo sapiens)6480464CTDTP53 gene affects the susceptibility to Doxorubicin; TP53 protein affects the susceptibility to DoxorubicinPMID:15182437 PMID:17085670 PMID:17912235 PMID:25124555 PMID:36634904
Tp53decreases expressionISOTrp53 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of TRP53 mRNAPMID:29653124
Tp53decreases expressionISOTP53 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of TP53 mRNAPMID:18510171
Tp53decreases response to substanceISOTrp53 (Mus musculus)6480464CTDTRP53 gene mutant form results in decreased susceptibility to Doxorubicin; TRP53 gene polymorphism results in decreased susceptibility to Doxorubicin; TRP53 protein mutant form results in decreased susceptibility to DoxorubicinPMID:16013437 PMID:16843502 PMID:17404018 PMID:19103993
Tp53decreases response to substanceISOTP53 (Homo sapiens)6480464CTDTP53 gene mutant form results in decreased susceptibility to Doxorubicin; TP53 protein mutant form results in decreased susceptibility to DoxorubicinPMID:15578696 PMID:17369602 PMID:31976328
Tp53increases acetylationISOTrp53 (Mus musculus)6480464CTDDoxorubicin results in increased acetylation of TRP53 proteinPMID:34713381
Tp53increases acetylationISOTP53 (Homo sapiens)6480464CTDDoxorubicin results in increased acetylation of TP53 protein; Doxorubicin results in increased acetylation of TP53 protein mutant formPMID:16826403 PMID:27129209
Tp53increases activityISOTrp53 (Mus musculus)6480464CTDDoxorubicin results in increased activity of TRP53 proteinPMID:12006519 PMID:16949053 PMID:24586632
Tp53increases activityISOTP53 (Homo sapiens)6480464CTDDoxorubicin results in increased activity of TP53 proteinPMID:15141020 PMID:17124180 PMID:22010212
Tp53increases exportISOTP53 (Homo sapiens)6480464CTDTP53 protein mutant form results in increased export of DoxorubicinPMID:31976328
Tp53increases expressionISOTrp53 (Mus musculus)6480464CTDDoxorubicin results in increased expression of TP53 protein; Doxorubicin results in increased expression of TRP53 mRNA; Doxorubicin results in increased expression of TRP53 protein; Doxorubicin results in increased expression of TRP53 protein modified formPMID:15458769 PMID:16949053 PMID:20144634 PMID:20363884 PMID:22763982 PMID:25665036 PMID:25896364 PMID:29653124 PMID:34713381 PMID:36811345
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of TP53; Doxorubicin results in increased expression of TP53 mRNA; Doxorubicin results in increased expression of TP53 protein; Doxorubicin results in increased expression of TP53 protein modified formPMID:10969820 PMID:11779855 PMID:12082016 PMID:14665630 PMID:15555623 PMID:15601469 PMID:15671536 PMID:15763944 PMID:15781256 PMID:15939500 PMID:16001973 PMID:16013437 PMID:16108013 PMID:16404146 PMID:16537896 PMID:16857806 PMID:17088865 PMID:17285121 PMID:17339365 PMID:17912235 PMID:17959036 PMID:18377724 PMID:19074854 PMID:19351845 PMID:19560264 PMID:20856197 PMID:20978201 PMID:21356574 PMID:21624110 PMID:22927544 PMID:26025680 PMID:26969377 PMID:27129209 PMID:34126102 PMID:34783124 PMID:36442531 PMID:36634904
Tp53increases glutathionylationISOTP53 (Homo sapiens)6480464CTDDoxorubicin results in increased glutathionylation of TP53 proteinPMID:17555331
Tp53increases phosphorylationISOTP53 (Homo sapiens)6480464CTDDoxorubicin results in increased phosphorylation of TP53 proteinPMID:15177039 PMID:15671536 PMID:19106633 PMID:20346999
Tp53increases response to substanceISOTrp53 (Mus musculus)6480464CTDTRP53 protein results in increased susceptibility to DoxorubicinPMID:10969820
Tp53increases response to substanceISOTP53 (Homo sapiens)6480464CTDTP53 protein results in increased susceptibility to DoxorubicinPMID:14704126 PMID:15601469 PMID:15823547 PMID:16211088 PMID:20856197 PMID:9395239
Tp53increases stabilityISOTP53 (Homo sapiens)6480464CTDDoxorubicin results in increased stability of TP53 proteinPMID:25124555
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]; [Doxorubicin affects the reaction [TRP53 protein binds to HSPB1 protein]] which results in increased expression of CDKN1A protein; [TRP53 protein results in decreased expression of SOD2 mRNA] which results in increased susceptibility to Doxorubicin; Celecoxib promotes the reaction [Doxorubicin results in increased expression of TRP53 protein]; Diclofenac promotes the reaction [Doxorubicin results in increased expression of TRP53 protein]; Doxorubicin affects the reaction [TRP53 protein binds to HSPB1 protein]; Doxorubicin promotes the reaction [[HSPB1 protein modified form results in increased activity of TRP53 protein] which results in increased expression of BAX protein]; Doxorubicin promotes the reaction [RELA protein binds to TRP53 protein]; Doxorubicin promotes the reaction [TDP 665759 results in increased expression of TRP53 protein]; Doxorubicin promotes the reaction [TRP53 protein binds to HSPB1 protein modified form]; Doxorubicin results in increased expression of and results in increased phosphorylation of TRP53 protein; Doxorubicin results in increased phosphorylation of and results in increased activity of TRP53 protein; HSF1 protein affects the reaction [Doxorubicin promotes the reaction [TRP53 protein binds to HSPB1 protein modified form]]; naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of TRP53 protein]; PSMB10 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; PSMB8 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; PSMB9 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]; SIRT1 protein affects the reaction [Doxorubicin results in increased expression of TRP53 protein]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]; sirtinol inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]; sulforaphane inhibits the reaction [TRP53 gene mutant form results in decreased susceptibility to Doxorubicin]; sulforaphane inhibits the reaction [TRP53 gene polymorphism results in decreased susceptibility to Doxorubicin]; TDP 665759 promotes the reaction [Doxorubicin results in increased expression of TRP53 protein]; TRP53 gene mutant form inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; TRP53 mutant form inhibits the reaction [Doxorubicin results in increased phosphorylation of STAT3 protein]; TRP53 protein mutant form affects the reaction [Doxorubicin results in increased activity of CASP3 protein]; TRP53 protein mutant form affects the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; TRP53 protein mutant form promotes the reaction [Doxorubicin results in increased expression of XRCC5 protein]; TRP53 protein mutant form promotes the reaction [Doxorubicin results in increased expression of XRCC6 protein]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]PMID:10969820 PMID:14766674 PMID:15458769 PMID:16013437 PMID:16432175 PMID:16843502 PMID:17404018 PMID:18263706 PMID:20363884 PMID:22242153 PMID:22763982 PMID:24586632 PMID:24812279 PMID:25665036 PMID:25896364 PMID:36811345
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT1 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; 7-monohydroxyethylrutoside inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; [Arsenic Trioxide co-treated with Doxorubicin co-treated with Magnetite Nanoparticles analog] affects the expression of TP53 mRNA; [Arsenic Trioxide co-treated with Doxorubicin co-treated with Magnetite Nanoparticles analog] affects the expression of TP53 protein; [Doxorubicin co-treated with Paclitaxel] results in increased expression of TP53 protein; [Doxorubicin co-treated with Resveratrol] results in increased expression of TP53 mRNA; [Doxorubicin co-treated with Resveratrol] results in increased expression of TP53 protein; [Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of TP53 protein; [Doxorubicin results in increased acetylation of TP53 protein mutant form] which results in increased expression of UBE2C protein; [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of BAX mRNA; [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of BBC3 mRNA; [NORAD co-treated with Doxorubicin] results in decreased expression of and results in decreased phosphorylation of TP53 protein; [Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of TP53 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of ABL1 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of ATM mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of ATR mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of ATRIP mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of ATRX mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of DDB2 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of ERCC2 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of EXO1 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of FANCD2 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of FANCG mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of FEN1 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of H2AX mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of LIG1 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of MAPK12 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of MCPH1 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of MDC1 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of MPG mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of MSH3 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of NBN mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of NTHL1 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of PCNA mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of PMS1 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of PNKP mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of POLH mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of PPM1D mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of PPP1R15A mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of RAD1 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of RAD17 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of RAD18 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of RAD21 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of RAD51 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of REV1 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of RNF168 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of RNF8 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of TOPBP1 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of XRCC1 mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of XRCC2 mRNA; Acetylcysteine inhibits the reaction [ATM protein promotes the reaction [Doxorubicin results in increased activity of TP53 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; ANGPT1 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; artenimol inhibits the reaction [TP53 protein mutant form results in increased export of Doxorubicin]; ATM protein promotes the reaction [Doxorubicin results in increased activity of TP53 protein]; Caffeine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; CDC25C protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Chloroquine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; cobaltous chloride inhibits the reaction [[Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of BAX mRNA]; cobaltous chloride inhibits the reaction [[Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of BBC3 mRNA]; cobaltous chloride inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]; cobaltous chloride inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]; CSE1L protein promotes the reaction [Doxorubicin results in increased expression of TP53 protein]; diethoxyphosphoryloxymethyl butanoate promotes the reaction [Doxorubicin results in increased acetylation of TP53 protein]; Doxorubicin inhibits the reaction [TP53 protein binds to KDM8 protein]; Doxorubicin inhibits the reaction [TP53 protein binds to MDM2 protein]; Doxorubicin promotes the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]; Doxorubicin promotes the reaction [[TP53 protein binds to BBC3 promoter] which results in increased expression of BBC3 mRNA]; Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]; Doxorubicin promotes the reaction [diethoxyphosphoryloxymethyl butanoate results in increased acetylation of TP53 protein]; Doxorubicin promotes the reaction [TP53 protein binds to BIRC5 promoter]; Doxorubicin promotes the reaction [TP53 protein binds to CARM1 protein]; Doxorubicin promotes the reaction [TP53 protein binds to CDKN1A promoter]; Doxorubicin promotes the reaction [TP53 protein binds to CREBBP protein]; Doxorubicin promotes the reaction [TP53 protein binds to ESR1 promoter]; Doxorubicin promotes the reaction [TP53 protein binds to JUN protein]; Doxorubicin promotes the reaction [TP53 protein binds to RRM2B promoter]; Doxorubicin promotes the reaction [TP53 protein binds to SP1 protein]; Doxorubicin results in increased expression of and affects the phosphorylation of and results in increased localization of TP53 protein; Doxorubicin results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein; Doxorubicin results in increased expression of and results in increased phosphorylation of TP53 protein; Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein; epigallocatechin gallate affects the reaction [Doxorubicin affects the expression of TP53 protein]; Fluorouracil promotes the reaction [[Doxorubicin co-treated with Paclitaxel] results in increased expression of TP53 protein]; ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of TP53 mRNA]; Glutathione inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]; IFNA1 protein promotes the reaction [Doxorubicin results in increased expression of TP53 protein]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; MDM2 protein inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]; MDM2 protein promotes the reaction [cobaltous chloride inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]]; NFKB1 protein affects the reaction [Doxorubicin results in increased expression of TP53 protein]; nutlin 3 promotes the reaction [Doxorubicin results in increased expression of TP53 protein]; Oxygen deficiency inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; PI103 inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; pluronic block copolymer p85 promotes the reaction [Doxorubicin results in increased expression of TP53 mRNA]; SETD7 protein promotes the reaction [Doxorubicin results in increased stability of TP53 protein]; TNF protein inhibits the reaction [TP53 gene mutant form results in decreased susceptibility to Doxorubicin]; TP53 affects the reaction [Doxorubicin results in increased activity of and results in increased expression of CDKN1A protein]; TP53 affects the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]]; TP53 gene mutant form inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; TP53 gene mutant form inhibits the reaction [Doxorubicin results in increased expression of ALOX12B mRNA]; TP53 gene mutant form inhibits the reaction [Doxorubicin results in increased expression of ALOX5 mRNA]; TP53 gene mutant form inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; TP53 protein affects the reaction [APP protein affects the susceptibility to Doxorubicin]; TP53 protein affects the reaction [CHEK1 protein affects the susceptibility to Doxorubicin]; TP53 protein affects the reaction [Doxorubicin affects the reaction [RELA protein results in increased expression of CDKN1A mRNA]]; TP53 protein affects the reaction [Doxorubicin results in decreased expression of BIRC5 protein]; TP53 protein affects the reaction [Doxorubicin results in decreased expression of EXO1 mRNA]; TP53 protein affects the reaction [Doxorubicin results in decreased expression of FANCD2 mRNA]; TP53 protein affects the reaction [Doxorubicin results in decreased expression of RAD1 mRNA]; TP53 protein affects the reaction [Doxorubicin results in decreased expression of RAD51 mRNA]; TP53 protein affects the reaction [Doxorubicin results in decreased expression of TERT mRNA]; TP53 protein affects the reaction [Doxorubicin results in decreased expression of TOPBP1 mRNA]; TP53 protein affects the reaction [Doxorubicin results in decreased expression of XRCC1 mRNA]; TP53 protein affects the reaction [Doxorubicin results in decreased expression of XRCC2 mRNA]; TP53 protein affects the reaction [Doxorubicin results in increased expression of ATRX mRNA]; TP53 protein affects the reaction [Doxorubicin results in increased expression of BAX protein]; TP53 protein affects the reaction [Doxorubicin results in increased expression of BBC3 protein]; TP53 protein affects the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; TP53 protein affects the reaction [Doxorubicin results in increased expression of ESR1 mRNA]; TP53 protein affects the reaction [Doxorubicin results in increased expression of ESR1 protein]; TP53 protein affects the reaction [Doxorubicin results in increased expression of GPX1 mRNA]; TP53 protein affects the reaction [Doxorubicin results in increased expression of NFKB1 protein]; TP53 protein affects the reaction [Doxorubicin results in increased expression of SOD2 mRNA]; TP53 protein affects the reaction [FHL2 protein affects the reaction [Doxorubicin results in increased expression of CDKN1A protein]]; TP53 protein affects the reaction [IFNA1 protein results in increased susceptibility to Doxorubicin]; TP53 protein inhibits the reaction [Doxorubicin results in decreased activity of CDK2 protein]; TP53 protein inhibits the reaction [Doxorubicin results in decreased expression of UBE2C protein]; TP53 protein inhibits the reaction [Sildenafil Citrate results in increased susceptibility to Doxorubicin]; TP53 protein mutant form affects the reaction [Doxorubicin results in decreased expression of BAX mRNA]; TP53 protein mutant form affects the reaction [Doxorubicin results in decreased expression of SFN mRNA]; TP53 protein mutant form affects the reaction [Doxorubicin results in increased expression of BAX protein]; TP53 protein mutant form affects the reaction [Doxorubicin results in increased expression of BBC3 protein]; TP53 protein mutant form affects the reaction [Doxorubicin results in increased expression of BCL2L1 protein]; TP53 protein mutant form affects the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; TP53 protein mutant form affects the reaction [Doxorubicin results in increased expression of SFN protein]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]]; TP53 protein promotes the reaction [[Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of BBC3 protein]; TP53 protein promotes the reaction [[Doxorubicin co-treated with PI103] results in increased expression of BBC3 protein]; TP53 protein promotes the reaction [Doxorubicin results in increased expression of ALOX12B mRNA]; TP53 protein promotes the reaction [Doxorubicin results in increased expression of ALOX5 mRNA]; TP53 protein promotes the reaction [Doxorubicin results in increased expression of FAS mRNA]; TP53 protein promotes the reaction [Doxorubicin results in increased expression of TNFSF10 mRNA]; TP53 protein promotes the reaction [Doxorubicin results in increased expression of TNFSF10 protein]; TP53 protein promotes the reaction [PI103 promotes the reaction [Doxorubicin results in increased activity of BAX protein]]; TP53 protein promotes the reaction [PI103 promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]; TP53 protein promotes the reaction [PI103 promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]; TP53 protein promotes the reaction [PI103 promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]]; TP53 protein results in increased susceptibility to [Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]; TP53 protein results in increased susceptibility to [Doxorubicin co-treated with PI103]; Wortmannin inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; zinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]PMID:11779855 PMID:15059885 PMID:15489221 PMID:15578696 PMID:15763944 PMID:15823547 PMID:15939500 PMID:16168113 PMID:16432175 PMID:16826403 PMID:17079232 PMID:17088865 PMID:17124180 PMID:17285121 PMID:17608641 PMID:17634554 PMID:17653088 PMID:17682292 PMID:17912235 PMID:17959036 PMID:18269916 PMID:18377724 PMID:18698031 PMID:19074854 PMID:19106633 PMID:19351845 PMID:19363521 PMID:19714248 PMID:20155316 PMID:20856197 PMID:21624110 PMID:22927544 PMID:24738333 PMID:24816189 PMID:25124555 PMID:26025680 PMID:26969377 PMID:27129209 PMID:27163855 PMID:27634759 PMID:30258081 PMID:31976328 PMID:34126102 PMID:34783124 PMID:35218280 PMID:36634904 PMID:37345903 PMID:37406984 PMID:9815696
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