GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Stat3 | decreases expression | EXP | | 6480464 | CTD | Doxorubicin results in decreased expression of STAT3 protein | PMID:35438302 | Stat3 | multiple interactions | EXP | | 6480464 | CTD | dapagliflozin inhibits the reaction [Doxorubicin results in decreased expression of STAT3 protein]; STAT3 protein promotes the reaction [dapagliflozin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]] | PMID:35438302 | Stat3 | affects response to substance | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | STAT3 protein affects the susceptibility to Doxorubicin | PMID:17920763 | Stat3 | decreases expression | ISO | Stat3 (Mus musculus) | 6480464 | CTD | Doxorubicin results in decreased expression of STAT3 mRNA | PMID:10618415 | Stat3 | decreases response to substance | ISO | Stat3 (Mus musculus) | 6480464 | CTD | STAT3 protein results in decreased susceptibility to Doxorubicin | PMID:11524388 | Stat3 | increases expression | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased expression of STAT3 mRNA; Doxorubicin results in increased expression of STAT3 protein | PMID:16001973 PMID:17920763 | Stat3 | increases phosphorylation | ISO | Stat3 (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of STAT3 protein | PMID:24812279 PMID:34605108 | Stat3 | increases response to substance | ISO | Stat3 (Mus musculus) | 6480464 | CTD | STAT3 gene mutant form results in increased susceptibility to Doxorubicin; STAT3 protein results in increased susceptibility to Doxorubicin | PMID:10618415 PMID:15781265 PMID:24812279 | Stat3 | multiple interactions | ISO | Stat3 (Mus musculus) | 6480464 | CTD | [[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of STAT3 mRNA; [STAT3 gene mutant form results in increased susceptibility to Doxorubicin] which results in increased activity of CASP3 protein; [STAT3 gene mutant form results in increased susceptibility to Doxorubicin] which results in increased cleavage of PARP1 protein; [STAT3 gene mutant form results in increased susceptibility to Doxorubicin] which results in increased expression of XRCC5 protein; [STAT3 gene mutant form results in increased susceptibility to Doxorubicin] which results in increased expression of XRCC6 protein; Doxorubicin promotes the reaction [thymoquinone results in decreased phosphorylation of STAT3 protein]; STAT3 gene mutant form promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]; STAT3 gene mutant form promotes the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; STAT3 gene mutant form promotes the reaction [Doxorubicin results in increased expression of XRCC5 protein]; STAT3 gene mutant form promotes the reaction [Doxorubicin results in increased expression of XRCC6 protein]; STAT3 protein promotes the reaction [Doxorubicin results in increased expression of NPPA mRNA]; thymoquinone inhibits the reaction [Doxorubicin results in increased phosphorylation of STAT3 protein]; TRP53 mutant form inhibits the reaction [Doxorubicin results in increased phosphorylation of STAT3 protein] | PMID:10618415 PMID:21040762 PMID:24812279 PMID:34605108 | | ||||||||||||||||||||||
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