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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3443
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptk2
Name: protein tyrosine kinase 2
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptk2decreases phosphorylationEXP 6480464CTDDoxorubicin results in decreased phosphorylation of PTK2 proteinPMID:16825486
Ptk2affects cleavageISOPTK2 (Homo sapiens)6480464CTDDoxorubicin affects the cleavage of PTK2 proteinPMID:15870702
Ptk2multiple interactionsISOPTK2 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PTK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]]; PTK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]PMID:16168102
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