Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3318
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1b
Name: ATP-binding cassette, sub-family B member 1B
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1bincreases expressionEXP 6480464CTDDoxorubicin results in increased expression of ABCB1B mRNA; Doxorubicin results in increased expression of ABCB1B proteinPMID:20961954 PMID:9815817
Abcb1baffects transportISOAbcb1b (Mus musculus)6480464CTDABCB1B protein affects the transport of DoxorubicinPMID:16611851
Abcb1bincreases response to substanceISOAbcb1b (Mus musculus)6480464CTDABCB1B gene mutant form results in increased susceptibility to DoxorubicinPMID:29462422
Abcb1bmultiple interactionsISOAbcb1b (Mus musculus)6480464CTD[Curcumin results in decreased expression of ABCB1B protein] which results in increased susceptibility to Doxorubicin; Lipopolysaccharides affects the reaction [ABCB1B protein results in increased secretion of Doxorubicin]PMID:15778272 PMID:18006147
Go Back to source page   Continue to Ontology report