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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of EDN1 mRNA; Doxorubicin results in increased expression of EDN1 proteinPMID:11589785 PMID:16766856 PMID:17974986
Edn1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]; EDN1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; RTKI cpd inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]PMID:14736733 PMID:17974986
Edn1increases activityISOEDN1 (Homo sapiens)6480464CTDDoxorubicin results in increased activity of EDN1 proteinPMID:7665224
Edn1increases expressionISOEdn1 (Mus musculus)6480464CTDDoxorubicin results in increased expression of EDN1 mRNA; Doxorubicin results in increased expression of EDN1 proteinPMID:17974986 PMID:18321777
Edn1increases expressionISOEDN1 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of EDN1 proteinPMID:17974986 PMID:7969316
Edn1multiple interactionsISOEdn1 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]; RTKI cpd inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]; TLR4 protein affects the reaction [Doxorubicin results in increased expression of EDN1 mRNA]; TLR4 protein affects the reaction [Doxorubicin results in increased expression of EDN1 protein]PMID:17974986 PMID:18321777
Edn1multiple interactionsISOEDN1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]; RTKI cpd inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]PMID:17974986
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