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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2286
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cbr1
Name: carbonyl reductase 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cbr1affects reductionISOCBR1 (Homo sapiens)6480464CTDCBR1 protein affects the reduction of DoxorubicinPMID:18635746
Cbr1decreases metabolic processingISOCBR1 (Homo sapiens)6480464CTDCBR1 gene SNP results in decreased metabolism of DoxorubicinPMID:19204081
Cbr1increases expressionISOCBR1 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of CBR1 proteinPMID:18755171
Cbr1increases reductionISOCBR1 (Homo sapiens)6480464CTDCBR1 protein results in increased reduction of DoxorubicinPMID:18755171
Cbr1increases response to substanceISOCbr1 (Mus musculus)6480464CTDCBR1 protein results in increased susceptibility to DoxorubicinPMID:11016643 PMID:14583452
Cbr1multiple interactionsISOCBR1 (Homo sapiens)6480464CTD[Resveratrol results in decreased activity of CBR1 protein] which affects the susceptibility to DoxorubicinPMID:24064738
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