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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1607086 Species: Homo sapiens RGD Object: Gene Symbol: SKP2 Name: S-phase kinase-associated protein 2, E3 ubiquitin protein ligase

Acc ID: CHEBI:28748 Term: doxorubicin Definition: An anthracycline antibiotic that has formula C27H29NO11. CasRN: 23214-92-8 Chemical ID: MESH:D004317

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	EXP		6480464	CTD	Doxorubicin affects the expression of SKP2 mRNA Doxorubicin affects the expression of SKP2 protein	PMID:17893511
affects response to substance	EXP		6480464	CTD	SKP2 protein affects the susceptibility to Doxorubicin	PMID:16217747