GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Atm | multiple interactions | EXP | | 6480464 | CTD | [Poly(ADP-ribose) Polymerase Inhibitors co-treated with Doxorubicin] results in increased phosphorylation of ATM protein | PMID:29913208 | Atm | decreases expression | ISO | ATM (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of ATM mRNA | PMID:22832221 | Atm | increases activity | ISO | ATM (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased activity of ATM protein | PMID:22927544 | Atm | increases expression | ISO | ATM (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased expression of ATM mRNA; Doxorubicin results in increased expression of ATM protein modified form | PMID:21184746 PMID:34783124 | Atm | increases phosphorylation | ISO | ATM (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of ATM protein | PMID:15489221 | Atm | multiple interactions | ISO | Atm (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of and results in increased activity of ATM protein | PMID:22242153 | Atm | multiple interactions | ISO | ATM (Homo sapiens) | 6480464 | CTD | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Doxorubicin results in increased activity of ATM protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of ATM protein]; [3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide affects the susceptibility to Doxorubicin] which results in increased expression of ATM mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of ATM mRNA; Acetylcysteine inhibits the reaction [ATM protein promotes the reaction [Doxorubicin results in increased activity of TP53 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK2 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of NBN protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of SMC1A protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of ATM protein]; ATM protein promotes the reaction [Doxorubicin results in increased activity of TP53 protein]; Caffeine inhibits the reaction [Doxorubicin results in increased activity of ATM protein]; Caffeine inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of ATM protein]; Doxorubicin inhibits the reaction [[RBBP8 protein binds to BRCA1 protein binds to E2F1 protein] which results in increased expression of ATM mRNA]; Doxorubicin inhibits the reaction [BRCA1 protein binds to ATM promoter]; Doxorubicin inhibits the reaction [Nocodazole inhibits the reaction [Hydroxyurea results in increased phosphorylation of ATM protein]]; Doxorubicin inhibits the reaction [RBBP8 protein binds to ATM promoter]; Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]; Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK2 protein]; Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of NBN protein]; Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of SMC1A protein]; Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]; Doxorubicin promotes the reaction [E2F1 protein results in decreased expression of ATM mRNA]; Doxorubicin results in increased phosphorylation of and results in increased activity of ATM protein; ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of ATM mRNA]; Wortmannin inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]] | PMID:15489221 PMID:18347191 PMID:22832221 PMID:22927544 PMID:31597699 PMID:34519926 PMID:34783124 PMID:36634904 | |
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