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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593265
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atm
Name: ATM serine/threonine kinase
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atmmultiple interactionsEXP 6480464CTD[Poly(ADP-ribose) Polymerase Inhibitors co-treated with Doxorubicin] results in increased phosphorylation of ATM proteinPMID:29913208
Atmdecreases expressionISOATM (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of ATM mRNAPMID:22832221
Atmincreases activityISOATM (Homo sapiens)6480464CTDDoxorubicin results in increased activity of ATM proteinPMID:22927544
Atmincreases expressionISOATM (Homo sapiens)6480464CTDDoxorubicin results in increased expression of ATM mRNA; Doxorubicin results in increased expression of ATM protein modified formPMID:21184746 PMID:34783124
Atmincreases phosphorylationISOATM (Homo sapiens)6480464CTDDoxorubicin results in increased phosphorylation of ATM proteinPMID:15489221
Atmmultiple interactionsISOAtm (Mus musculus)6480464CTDDoxorubicin results in increased phosphorylation of and results in increased activity of ATM proteinPMID:22242153
Atmmultiple interactionsISOATM (Homo sapiens)6480464CTD2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Doxorubicin results in increased activity of ATM protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of ATM protein]; [3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide affects the susceptibility to Doxorubicin] which results in increased expression of ATM mRNA; [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of ATM mRNA; Acetylcysteine inhibits the reaction [ATM protein promotes the reaction [Doxorubicin results in increased activity of TP53 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK2 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of NBN protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of SMC1A protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of ATM protein]; ATM protein promotes the reaction [Doxorubicin results in increased activity of TP53 protein]; Caffeine inhibits the reaction [Doxorubicin results in increased activity of ATM protein]; Caffeine inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of ATM protein]; Doxorubicin inhibits the reaction [[RBBP8 protein binds to BRCA1 protein binds to E2F1 protein] which results in increased expression of ATM mRNA]; Doxorubicin inhibits the reaction [BRCA1 protein binds to ATM promoter]; Doxorubicin inhibits the reaction [Nocodazole inhibits the reaction [Hydroxyurea results in increased phosphorylation of ATM protein]]; Doxorubicin inhibits the reaction [RBBP8 protein binds to ATM promoter]; Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]; Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK2 protein]; Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of NBN protein]; Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of SMC1A protein]; Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]; Doxorubicin promotes the reaction [E2F1 protein results in decreased expression of ATM mRNA]; Doxorubicin results in increased phosphorylation of and results in increased activity of ATM protein; ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of ATM mRNA]; Wortmannin inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]PMID:15489221 PMID:18347191 PMID:22832221 PMID:22927544 PMID:31597699 PMID:34519926 PMID:34783124 PMID:36634904
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