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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305769
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pink1
Name: PTEN induced kinase 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pink1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of PINK1 proteinPMID:26678157 PMID:29966675
Pink1multiple interactionsEXP 6480464CTDMelatonin inhibits the reaction [Doxorubicin results in increased expression of PINK1 protein]PMID:29966675
Pink1increases expressionISOPINK1 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of PINK1 proteinPMID:29729358
Pink1multiple interactionsISOPINK1 (Homo sapiens)6480464CTD3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Doxorubicin results in increased expression of PINK1 protein]; MitoTEMPO inhibits the reaction [Doxorubicin results in increased expression of PINK1 protein]PMID:29729358
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