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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10643 Species: Mus musculus RGD Object: Gene Symbol: Gh Name: growth hormone

Acc ID: CHEBI:28748 Term: doxorubicin Definition: An anthracycline antibiotic that has formula C27H29NO11. CasRN: 23214-92-8 Chemical ID: MESH:D004317

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:2686	6480464	CTD	[Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein] [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein] [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]	PMID:20051877