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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10439 Species: Mus musculus RGD Object: Gene Symbol: Cyp1b1 Name: cytochrome P450, family 1, subfamily b, polypeptide 1

Acc ID: CHEBI:28748 Term: doxorubicin Definition: An anthracycline antibiotic that has formula C27H29NO11. CasRN: 23214-92-8 Chemical ID: MESH:D004317

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:2460	6480464	CTD	Doxorubicin results in increased expression of CYP1B1 protein Doxorubicin results in increased expression of CYP1B1 mRNA	PMID:19796650
increases expression	EXP		6480464	CTD	Doxorubicin results in increased expression of CYP1B1 mRNA	PMID:21040762
multiple interactions	EXP		6480464	CTD	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of CYP1B1 mRNA	PMID:21040762