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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:28744
Term: 2-hydroxy-17beta-estradiol
Definition: A 2-hydroxy steroid that consists of 17beta-estradiol having an additional hydroxy group at position 2.
Chemical ID: MESH:C001390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases chemical synthesisISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiolPMID:16790556
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTDCarbaryl inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Chlorpyrifos inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Fonofos inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; naphthalene inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]PMID:16790556
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