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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733062 Species: Mus musculus RGD Object: Gene Symbol: Bad Name: BCL2-associated agonist of cell death

Acc ID: CHEBI:28741 Term: sodium fluoride Definition: A metal fluoride salt with a Na(+) counterion. CasRN: 7681-49-4 Chemical ID: MESH:D012969

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:735541	6480464	CTD	Sodium Fluoride inhibits the reaction [CA2 protein binds to BAD protein] Sodium Fluoride promotes the reaction [BAD protein binds to BCL2 protein] [Sodium Fluoride inhibits the reaction [CA2 protein binds to BAD protein]] promotes the reaction [BAD protein binds to BCL2 protein] Sodium Fluoride results in increased expression of and results in decreased phosphorylation of BAD protein	PMID:21708216