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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732101 Species: Homo sapiens RGD Object: Gene Symbol: KCNH2 Name: potassium voltage-gated channel, subfamily H (eag-related), member 2

Acc ID: CHEBI:28593 Term: quinidine Definition: A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy. CasRN: 56-54-2 Chemical ID: MESH:D011802

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Acids inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]	PMID:15821840
decreases response to substance	EXP		6480464	CTD	KCNH2 gene mutant form results in decreased susceptibility to Quinidine	PMID:15673388
affects response to substance	EXP		6480464	CTD	KCNH2 gene SNP affects the susceptibility to Quinidine	PMID:12695533
multiple interactions	EXP		6480464	CTD	naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein] Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein]	PMID:18057881
multiple interactions	EXP		6480464	CTD	Potassium inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]	PMID:16960444
affects localization	EXP		6480464	CTD	Quinidine affects the localization of KCNH2 protein mutant form	PMID:11741928
affects binding	EXP		6480464	CTD	Quinidine binds to KCNH2 protein	PMID:18701618
decreases activity	EXP		6480464	CTD	Quinidine results in decreased activity of KCNH2 protein	PMID:15671647 PMID:16960444 PMID:15673388 PMID:17042915 PMID:11741928 PMID:18724381 PMID:12695533 PMID:15821840 PMID:18057881
decreases activity	EXP		6480464	CTD	Quinidine results in decreased activity of KCNH2 protein	PMID:11741928 PMID:18057881 PMID:12695533 PMID:17042915 PMID:15673388 PMID:15671647 PMID:18724381 PMID:15821840 PMID:16960444
decreases activity	EXP		6480464	CTD	Quinidine results in decreased activity of KCNH2 protein	PMID:11741928 PMID:15821840 PMID:16960444 PMID:15673388 PMID:15671647 PMID:12695533 PMID:17042915 PMID:18724381 PMID:18057881
affects activity	EXP		6480464	CTD	Quinidine affects the activity of KCNH2 protein	PMID:22020101
decreases activity	EXP		6480464	CTD	Quinidine results in decreased activity of KCNH2 protein	PMID:12695533 PMID:15671647 PMID:16960444 PMID:15821840 PMID:18724381 PMID:11741928 PMID:18057881 PMID:17042915 PMID:15673388
decreases activity	EXP		6480464	CTD	Quinidine results in decreased activity of KCNH2 protein	PMID:12695533 PMID:16960444 PMID:15671647 PMID:17042915 PMID:11741928 PMID:18057881 PMID:18724381 PMID:15673388 PMID:15821840
decreases activity	EXP		6480464	CTD	Quinidine results in decreased activity of KCNH2 protein	PMID:15671647 PMID:18724381 PMID:12695533 PMID:11741928 PMID:16960444 PMID:15673388 PMID:17042915 PMID:15821840 PMID:18057881
decreases activity	EXP		6480464	CTD	Quinidine results in decreased activity of KCNH2 protein	PMID:11741928 PMID:12695533 PMID:15671647 PMID:15673388 PMID:15821840 PMID:16960444 PMID:17042915 PMID:18057881 PMID:18724381 PMID:21362439