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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3637
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scn5a
Name: sodium voltage-gated channel alpha subunit 5
Acc ID: CHEBI:28462
Term: ajmaline
Definition: A monoterpenoid indole alkaloid that consists of ajmalan substituted at positions 17 and 21 by hydroxy groups.
Chemical ID: MESH:D000404
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scn5aaffects response to substanceISOSCN5A (Homo sapiens)6480464CTDSCN5A protein affects the susceptibility to AjmalinePMID:10662748 PMID:15520322
Scn5adecreases activityISOScn5a (Mus musculus)6480464CTDAjmaline results in decreased activity of SCN5A proteinPMID:20174578
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