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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708428 Species: Rattus norvegicus RGD Object: Gene Symbol: Akr1c3 Name: aldo-keto reductase family 1, member C3

Acc ID: CHEBI:28453 Term: (20S)-20-hydroxypregn-4-en-3-one Definition: A 20-hydroxypregn-4-en-3-one that has formula C21H32O2. CasRN: 145-14-2 Chemical ID: MESH:D004092

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1352888	6480464	CTD	[AKR1C3 protein results in increased metabolism of Progesterone] which results in increased chemical synthesis of 20-alpha-Dihydroprogesterone	PMID:19010312
increases chemical synthesis	EXP		6480464	CTD	AKR1C18 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone	PMID:8172618
multiple interactions	ISO	RGD:1352888	6480464	CTD	[AKR1C3 protein results in increased reduction of Progesterone] which results in increased chemical synthesis of 20-alpha-Dihydroprogesterone	PMID:20036328