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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305471 Species: Rattus norvegicus RGD Object: Gene Symbol: Atf6 Name: activating transcription factor 6

Acc ID: CHEBI:28393 Term: beta-D-glucosamine Definition: A 2-amino-2-deoxy-D-glucopyranose that has formula C6H13NO5. CasRN: 3416-24-8 Chemical ID: MESH:D005944

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1313517	6480464	CTD	4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA] ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA] ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein] ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA] ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein] ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA] ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein] tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]	PMID:20165829
increases expression	ISO	RGD:1313517	6480464	CTD	Glucosamine results in increased expression of ATF6 mRNA	PMID:20165829 PMID:19383982
decreases expression	ISO	RGD:1313518	6480464	CTD	Glucosamine results in decreased expression of ATF6 mRNA	PMID:17178593
multiple interactions	EXP		6480464	CTD	4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA] ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA] ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA] ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein] ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein] ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA] ATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein] tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]	PMID:20165829
increases expression	EXP		6480464	CTD	Glucosamine results in increased expression of ATF6 mRNA	PMID:20165829
increases expression	ISO	RGD:1313517	6480464	CTD	Glucosamine results in increased expression of ATF6 mRNA	PMID:19383982 PMID:20165829