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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732290 Species: Homo sapiens RGD Object: Gene Symbol: FGFR1 Name: fibroblast growth factor receptor 1

Acc ID: CHEBI:28304 Term: heparin Definition: A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1->4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule. CasRN: 9005-49-6 Chemical ID: MESH:D006493

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects binding	EXP		6480464	CTD	Heparin binds to FGFR1 protein binds to FGF2 protein	PMID:15096041
multiple interactions	ISO	RGD:732291	6480464	CTD	Heparin promotes the reaction [FGFR1 protein binds to FGF1 protein] Heparin promotes the reaction [FGFR1 protein binds to FGF2 protein]	PMID:1379594