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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11275 Species: Mus musculus RGD Object: Gene Symbol: Ccl2 Name: chemokine (C-C motif) ligand 2

Acc ID: CHEBI:28262 Term: dimethyl sulfoxide Definition: A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents. CasRN: 67-68-5 Chemical ID: MESH:D004121

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:731046	6480464	CTD	Dimethyl Sulfoxide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] Dimethyl Sulfoxide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]	PMID:17529908
multiple interactions	ISO	RGD:731046	6480464	CTD	Dimethyl Sulfoxide inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]	PMID:14576080
decreases expression	ISO	RGD:3645	6480464	CTD	Dimethyl Sulfoxide results in decreased expression of CCL2 mRNA	PMID:10925121
multiple interactions	ISO	RGD:731046	6480464	CTD	Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]	PMID:21878375
multiple interactions	ISO	RGD:3645	6480464	CTD	Dimethyl Sulfoxide inhibits the reaction [sodium arsenite results in increased expression of CCL2 mRNA]	PMID:15689417