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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708425
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Havcr1
Name: hepatitis A virus cellular receptor 1
Acc ID: CHEBI:2825
Term: aristolochic acid A
Definition: An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Chemical ID: MESH:C000228
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Havcr1increases expressionEXP 6480464CTDaristolochic acid I results in increased expression of HAVCR1 proteinPMID:35690179
Havcr1decreases expressionISOHAVCR1 (Homo sapiens)6480464CTDaristolochic acid I results in decreased expression of HAVCR1 mRNA; aristolochic acid I results in decreased expression of HAVCR1 proteinPMID:33212167
Havcr1increases expressionISOHAVCR1 (Homo sapiens)6480464CTDaristolochic acid I results in increased expression of HAVCR1 proteinPMID:34677723
Havcr1increases expressionISOHavcr1 (Mus musculus)6480464CTDaristolochic acid I results in increased expression of HAVCR1 proteinPMID:23019274 PMID:34677723
Havcr1multiple interactionsISOHAVCR1 (Homo sapiens)6480464CTD[LRG1 protein results in increased susceptibility to aristolochic acid I] which results in increased expression of HAVCR1 protein; TGFBR1 mRNA promotes the reaction [[LRG1 protein results in increased susceptibility to aristolochic acid I] which results in increased expression of HAVCR1 protein]PMID:34677723
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