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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:28216
Term: methylmercury chloride
Definition: A chlorine molecular entity that has formula CH3ClHg.
Chemical ID: MESH:C004925
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionEXP 6480464CTDmethylmercuric chloride results in decreased expression of VEGFA proteinPMID:31850806
Vegfaincreases expressionEXP 6480464CTDmethylmercuric chloride results in increased expression of VEGFA mRNA; methylmercuric chloride results in increased expression of VEGFA proteinPMID:28526320
Vegfamultiple interactionsEXP 6480464CTD2-Methoxyestradiol promotes the reaction [methylmercuric chloride results in decreased expression of VEGFA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [methylmercuric chloride results in decreased expression of VEGFA protein]; cobaltous chloride inhibits the reaction [methylmercuric chloride results in decreased expression of VEGFA protein]; protocatechuic acid inhibits the reaction [methylmercuric chloride results in decreased expression of VEGFA protein]PMID:31850806
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDmethylmercuric chloride results in decreased expression of VEGFA mRNAPMID:23179753 PMID:27188386
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDmethylmercuric chloride results in increased expression of VEGFA mRNAPMID:23179753 PMID:26272509 PMID:28001369 PMID:34089799
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD[NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of VEGFA mRNAPMID:27188386
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