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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityEXP 6480464CTDRotenone results in decreased activity of GSR proteinPMID:26446018 PMID:28389404 PMID:30472438
Gsrmultiple interactionsEXP 6480464CTD1-(1-acetyl-piperidine-4-yl)-3-adamantan-1-yl-urea inhibits the reaction [Rotenone results in decreased activity of GSR protein]; Apigenin inhibits the reaction [Rotenone results in decreased activity of GSR protein]; salubrinal inhibits the reaction [Rotenone results in decreased activity of GSR protein]PMID:26446018 PMID:28389404 PMID:30472438
Gsraffects expressionISOGsr (Mus musculus)6480464CTDRotenone affects the expression of GSR mRNAPMID:23186747
Gsrincreases expressionISOGSR (Homo sapiens)6480464CTDRotenone results in increased expression of GSR mRNAPMID:33512557 PMID:36586010
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